Anti-FOXN1 antibody
Specifications
| Product Cat#: | AB-06-1755 |
| Product type: | Primary antibody |
| Antigen: | FOXN1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human FOXN1 321-420/648 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-1:800); Flow Cytometry (1.5ug/Test) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA; 50% glycerol, 0.03% Proclin |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | FKHL20 |
| Forkhead box N1 | |
| Forkhead box protein N1 | |
| FOXN1 | |
| FOXN1 | |
| FOXN1_HUMAN | |
| RONU | |
| Rowett nude | |
| Transcription factor winged-helix nude | |
| WHN | |
| Winged helix nude |
Target information
Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny .
Provider
Erpantech Laboratory
