Anti-FE65 antibody
Specifications
| Product Cat#: | AB-06-1689 |
| Product type: | Primary antibody |
| Antigen: | FE65 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Fe65 protein 201-300/710 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Human, Mouse, Rat, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS(pH7.4) with 1% BSA; 0.03% Proclin 300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Adaptor protein FE65a2 |
| Amyloid beta (A4) precursor protein binding family B member 1 | |
| Amyloid beta A4 precursor protein binding family B | |
| Amyloid beta A4 precursor protein binding family B member 1 | |
| Amyloid beta precursor protein binding family B member 1 | |
| APBB1 | |
| APBB1 | |
| FE65 | |
| Fe65 protein | |
| MGC 072 | |
| MGC9072 | |
| Protein Fe65 | |
| RIR | |
| Stat like protein | |
| Fe-65 Protein |
Target information
Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on ‘Tyr-142’ (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Provider
Erpantech Laboratory
