Anti-FCHO2 antibody
Specifications
| Product Cat#: | AB-08-0112 |
| Product type: | Primary antibody |
| Antigen: | FCHO2 |
| Immunogen: | Recombinant protein containing a sequence corresponding to amino acids 1-300 of human FCHO2. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.3), 50% Glycerol, 0.02% NaN3. |
| Purity: | Immunogen affinity purified |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | FCH And Mu Domain Containing Endocytic Adaptor 2; F-BAR Domain Only Protein 2; FCH Domain Only 2; FCH Domain Only Protein 2 |
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Target information
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
Provider
Erpantech Laboratory
