Anti-FBXW7 antibody
Specifications
| Product Cat#: | AB-06-1684 |
| Product type: | Primary antibody |
| Antigen: | FBXW7 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:50-1:200); Immunocytochemistry (1:450-1:2000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.5% BSA; 50% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AGO antibody |
| Archipelago antibody | |
| Archipelago homolog antibody | |
| Archipelago, Drosophila, homolog of antibody | |
| CDC4 antibody | |
| CDC4, S.cerevisiae, homolog of antibody | |
| DKFZp686F23254 antibody | |
| F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody | |
| F box and WD 40 domain protein 7 antibody | |
| F box and WD repeat domain containing 7 antibody | |
| F box protein FBW7 antibody | |
| F box protein FBX30 antibody | |
| F box protein SEL 10 antibody | |
| F box protein SEL10 antibody | |
| F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody | |
| F-box and WD-40 domain-containing protein 7 antibody | |
| F-box protein FBX30 antibody | |
| F-box/WD repeat-containing protein 7 antibody | |
| FBW6 antibody | |
| FBW7 antibody | |
| FBX30 antibody | |
| FBXO30 antibody | |
| FBXW6 antibody | |
| FBXW7 antibody | |
| FBXW7_HUMAN antibody | |
| FLJ16457 antibody | |
| HAgo antibody | |
| HCdc4 antibody | |
| Homolog of C elegans sel 10 antibody | |
| Homolog of C.elegans sel10 antibody | |
| SEL 10 antibody |
Target information
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination . Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation . SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation . Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination .
Provider
Erpantech Laboratory
