Anti-FBXO36 antibody
Specifications
| Product Cat#: | AB-06-1682 |
| Product type: | Primary antibody |
| Antigen: | FBXO36 |
| Immunogen: | KLH conjugated synthetic peptide derived from human FBXO6 1-100/188 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:450-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Cow, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS(pH7.4) with 1% BSA; 0.03% Proclin 300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | F box only protein 36 |
| F box protein 36 | |
| F-box only protein 36 | |
| Fbx36 | |
| Fbx36 | |
| FBX36_HUMAN | |
| FBXO36 | |
| Fbxo36 | |
| FLJ37592 |
Target information
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on ‘Ser-345’), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
Provider
Erpantech Laboratory
