Anti-FBXL17 antibody
Specifications
| Product Cat#: | AB-06-1677 |
| Product type: | Primary antibody |
| Antigen: | FBXL17 |
| Immunogen: | KLH conjugated synthetic peptide derived from human FBXL17 451-550/701 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS(pH7.4) with 1% BSA; 0.03% Proclin 300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | F box and leucine rich repeat protein 17 |
| F box only protein 13 | |
| F box/LRR repeat protein 17 | |
| F-box and leucine-rich repeat protein 17 | |
| F-box only protein 13 | |
| F-box/LRR-repeat protein 17 | |
| FBL17 | |
| FBX13 | |
| Fbxl17 | |
| FBXO13 | |
| FBXL13 | |
| FXL17_HUMAN |
Target information
Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) . FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 . The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction . The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity).
Provider
Erpantech Laboratory
