Anti-FADS1 antibody
Specifications
| Product Cat#: | AB-06=1643 |
| Product type: | Primary antibody |
| Antigen: | FADS1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human FADS1 381-444/444 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:450-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS(pH7.4) with 1% BSA;0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Delta 5 desaturase |
| Delta 5 fatty acid desaturase | |
| FADS6 | |
| FADSD5 | |
| D5D antibody Fatty acid desaturase 1 | |
| FLJ38956 | |
| Linoleoyl CoA desaturase (delta 6 desaturase) like 1 | |
| LLCDL1 | |
| TU12 |
Target information
Isoform 1: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively . As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity).
Provider
Erpantech Laboratory
