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Anti-EZH2 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-1627
Anti-EZH2 antibody
Erpan Tech In stock

Specifications        

Product cat: AB-06-1627
Product type: Primary antibody
Antigen: EZH2
Immunogen: Recombinant protein
Species immunized: Mouse
Isotype: IgG1
Applications: Western Blot (1:900-1:2400); Immunohistochemistry (1:90-1:260); Flow Cytometry (1:70-1:260)
Reactivity: Human
Clonality (clone number): Monoclonal (6F-4G)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Enhancer of zeste 2 antibody
enhancer of zeste 2 polycomb repressive complex 2 subunit antibody
Enhancer of zeste homolog 2 (Drosophila) antibody
Enhancer of zeste homolog 2 antibody
Enhancer of zeste, Drosophila, homolog 2 antibody
ENX 1 antibody
Enx 1h antibody
ENX-1 antibody
ENX1 antibody
Enx1h antibody
EZH 2 antibody
EZH1 antibody
EZH2 antibody
EZH2_HUMAN antibody
EZH2b antibody
Histone-lysine N-methyltransferase EZH2 antibody
KMT 6 antibody
KMT6 antibody
KMT6A antibody
Lysine N-methyltransferase 6 antibody
MGC9169 antibody
WVS antibody
WVS2 antibody
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Target information

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates ‘Lys-9’ (H3K9me) and ‘Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate ‘Lys-27’ of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of ‘Lys-27’ of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.

Provider

Erpantech Laboratory

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