Anti-ESR1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | ESR1 |
| Immunogen: | This antibody is produced by immunizing rabbits with |
| a synthetic peptide (KLH-coupled) corresponding to a region of C-terminal | |
| residues of human ESR1. | |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:2000);Flow Cytometry (1:100-1:200);Immunocytochemistry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Immunogen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DKFZp686N23123 antibody |
| ER alpha antibody | |
| ER antibody | |
| ER-alpha antibody | |
| Era antibody | |
| ESR antibody | |
| ESR1 antibody | |
| ESR1_HUMAN antibody | |
| ESRA antibody | |
| Estradiol receptor antibody | |
| Estrogen nuclear receptor alpha antibody | |
| Estrogen receptor 1 antibody | |
| Estrogen receptor alpha 3*,4,5,6,7*/822 isoform antibody | |
| Estrogen receptor alpha antibody | |
| Estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform antibody | |
| Estrogen receptor alpha delta 3*,4,5,6,7*/819 2 isoform antibody | |
| Estrogen receptor alpha delta 4 +49 isoform antibody | |
| Estrogen receptor alpha delta 4*,5,6,7*/654 isoform antibody | |
| Estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform antibody | |
| Estrogen receptor alpha E1 E2 1 2 antibody | |
| Estrogen receptor alpha E1 N2 E2 1 2 antibody | |
| Estrogen receptor antibody | |
| ESTRR antibody | |
| NR3A1 antibody | |
| Nuclear receptor subfamily 3 group A member 1 antibody |
Target information
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter.
Provider
Erpantech Laboratory
