Anti-Erk1/2 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Erk1/2 |
| Immunogen: | Amino acids 325-345 of ERK 1 of rat origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot( 1:100=1:1000 ); Immunoprecipitation( 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) ); Immunofluorescence(1：50-1:400) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal(2G1) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | ProA affinity purified |
| Storage: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Alternative names: | ERK 1 antibody |
| ERK antibody | |
| ERK-2 antibody | |
| ERK1 antibody | |
| ERK2 antibody | |
| ERT1 antibody | |
| Extracellular signal regulated kinase 1 antibody | |
| Extracellular signal related kinase 1 antibody | |
| Extracellular signal-regulated kinase 2 antibody | |
| HUMKER1A antibody | |
| Insulin stimulated MAP2 kinase antibody | |
| MAP kinase 1 antibody | |
| MAP kinase 2 antibody | |
| MAP kinase 3 antibody | |
| MAP kinase isoform p42 antibody | |
| MAP kinase isoform p44 antibody | |
| MAPK 1 antibody | |
| MAPK 2 antibody | |
| Mapk1 antibody | |
| MAPK2 antibody | |
| MAPK3 antibody | |
| Microtubule associated protein 2 kinase antibody | |
| Mitogen activated protein kinase 3 antibody | |
| Mitogen-activated protein kinase 1 antibody | |
| Mitogen-activated protein kinase 2 antibody | |
| MK01_HUMAN antibody | |
| p38 antibody | |
| p40 antibody | |
| p41 antibody | |
| p41mapk antibody | |
| p42-MAPK antibody | |
| P42MAPK antibody | |
| p44 ERK1 antibody | |
| p44 MAPK antibody | |
| P44ERK1 antibody | |
| P44MAPK antibody | |
| PRKM1 antibody | |
| PRKM2 antibody | |
| PRKM3 antibody | |
| Protein tyrosine kinase ERK2 antibody |
Target information
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis.
Provider
Erpantech Laboratory