Anti-Epac1 antibody
Specifications
| Product cat: | AB-06-1561 |
| Product type: | Primary antibody |
| Antigen: | Epac1 |
| Immunogen: | Amino acids 1-70 of Epac of human origin |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:90-1:1000); Immunohistochemistry (1:60-1:500); Immunofluorescence (1:40-1:500); Immunoprecipitation (1-3 μg per 100-500 μg of total protein(1 ml of cell lysate)) |
| Reactivity: | Rat, Human, Hamster |
| Clonality (clone number): | Monoclonal (4G3) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | bcm910 antibody |
| CAMP GEFI antibody | |
| cAMP regulated guanine nucleotide exchange factor I antibody | |
| CAMPGEFI antibody | |
| CGEF 1 antibody | |
| CGEF1 antibody | |
| EPA1 antibody | |
| Epac 1 antibody | |
| EPAC antibody | |
| EPAC1 antibody | |
| Exchange factor directly activated by cAMP 1 antibody | |
| Exchange protein directly activated by cAMP 1 antibody | |
| MGC21410 antibody | |
| RAP guanine nucleotide exchange factor antibody | |
| Rap guanine nucleotide exchange factor (GEF) 3 antibody | |
| RAP guanine nucleotide exchange factor 3 antibody | |
| Rap1 guanine nucleotide exchange factor directly activated by cAMP antibody |
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Target information
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Provider
Erpantech Laboratory
