Anti-EMC4 antibody
Specifications
| Product Cat#: | AB-06-4913 |
| Product type: | Primary antibody |
| Antigen: | EMC4 |
| Immunogen: | Synthetic peptide within human EMC4 aa 21-70/183. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:5000); Immunohistochemistry-Paraffin (1:100-1:400) |
| Reactivity: | Human, Rat, Mouse |
| Clonality (clone number): | Monoclonal, JE65-17 |
| Form: | Liquid |
| Buffer: | 1*TBS buffer (pH7.4), 0.05% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | Cell proliferation-inducing gene 17 protein antibody |
| EMC4 antibody | |
| ER membrane protein complex subunit 4 antibody | |
| HSPC184 antibody | |
| PIG17 antibody | |
| Tmem85 antibody | |
| TMM85_HUMAN antibody | |
| Transmembrane protein 85 antibody |
Target information
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656).
Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231).
Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151).
It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231).
By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835).
By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
Provider
Erpantech Laboratory