Anti-EIF2AK2 antibody
Specifications
| Product Cat#: | AB-06-1522 |
| Product type: | Primary antibody |
| Antigen: | EIF2AK2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:800-1:2000); Immunohistochemistry (1:180-1:500);Flow Cytometry (1:80-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (3A-H10) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Double Stranded RNA Activated Protein Kinase; Antibody |
| E2AK2_HUMAN Antibody | |
| eIF-2A Protein Kinase 2Antibody | |
| EIF2AK1 Antibody | |
| EIF2AK2 Antibody | |
| Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2 Antibody | |
| Eukaryotic Translation Initiation Factor 2-alpha kinase 2 Antibody | |
| HGNC:9437 antibody | |
| Interferon Induced Double Stranded RNA Activated Protein Kinase Antibody | |
| Interferon Inducible elF2 Alpha Kinase Antibody | |
| Interferon Inducible RNA Dependent Protein Kinase Antibody | |
| Interferon-induced, Double-stranded RNA-activated Protein Kinase Antibody | |
| Interferon-inducible RNA-dependent Protein Kinase Antibody | |
| MGC126524 Antibody | |
| P1/eIF-2A Protein Kinase Antibody | |
| P1/eIF2A protein kinase Antibody | |
| p68 Kinase Antibody | |
| PKR Antibody | |
| PPP1R83 Antibody | |
| PRKR Antibody | |
| Protein Kinase Interferon Inducible Double Stranded RNA Dependent Antibody | |
| Protein Kinase RNA Activated Antibody | |
| Protein Kinase RNA-activated Antibody | |
| Protein Phosphatase 1 Regulatory Subunit 83 Antibody |
Target information
Interferon-inducible RNA-dependent protein serine/threonine kinase, PKR, is variously designated in earlier literature as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68, eIF-2α protein kinase or p69 for the human kinase. The PKR kinase substrate is the α subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2α on serine-51 results in inhibition of translation. Molecular cDNA clones have been isolated from both human and mouse cells. The serine/threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. Three kinds of regulation of PKR enzymatic activity have been described. These include transcriptional regulation in response to interferon, an autoregulatory mechanism controlling PKR expression at the level of translation and post-translational regulation by RNA-mediated autophosphorylation.
Provider
Erpantech Laboratory
