Anti-DR6 antibody
Specifications
| Product Cat#: | AB-06-1451 |
| Product type: | Primary antibody |
| Antigen: | DR6 |
| Immunogen: | KLH conjugated synthetic peptide derived from human DR6/CD358 101-200/655 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | TNFRSF 21 |
| BM 018 | |
| BM018 | |
| CD358 | |
| Death receptor 6 | |
| DR 6 | |
| MGC31965 | |
| TNFR related death receptor 6 | |
| TNFRSF21 | |
| TNFRSF21 protein | |
| TNR21_HUMAN | |
| Tumor necrosis factor receptor superfamily member 21 |
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Target information
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Provider
Erpantech Laboratory