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Anti-Dnmt3b antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-1424
Anti-Dnmt3b antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-1424
Product type: Primary antibody
Antigen: Dnmt3b
Immunogen: Synthetic peptide within human Dnmt3b aa 1-50.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:400-1:1000); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:50-1:200); Immunocytochemistry (1:100-1:200)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: TBS (pH7.4), 0.5% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Peptide affinity purified.
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Cytosine 5methyltransferase 3B antibody
DNA antibody
DNA (cytosine 5) methyltransferase 3 beta antibody
DNA (cytosine 5)-methyltransferase 3B antibody
DNA (cytosine-5)-methyltransferase 3B antibody
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Dnmt3b antibody
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Target information

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells.

Provider

Erpantech Laboratory

download

MSDS-AB-06-1424.pdf (143 downloads)