Anti-DNase I antibody
Specifications
| Product Cat#: | AB-06-1417 |
| Product type: | Primary antibody |
| Antigen: | DNase I |
| Immunogen: | KLH conjugated synthetic peptide derived from human DNase I 101-200/282 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | RNASE1 |
| Dornase alfa | |
| Deoxyribonuclease 1 | |
| Deoxyribonuclease I | |
| Deoxyribonuclease1 | |
| DeoxyribonucleaseI | |
| DNASE 1 | |
| DNase I lysosomal | |
| DNASE1 | |
| DNaseI | |
| DNL 1 | |
| DNL1 | |
| DRNI | |
| Human urine deoxyribonuclease I |
Target information
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
Provider
Erpantech Laboratory
