Anti-DNA-PKcs/PRKDC antibody
Specifications
| Product Cat#: | AB-06-1415 |
| Product type: | Primary antibody |
| Antigen: | DNA-PKcs/PRKDC |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:800); Immunohistochemistry (1:100); Immunocytochemistry (1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (2-B3) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DNA dependent protein kinase catalytic subunit antibody |
| DNA PK catalytic subunit antibody | |
| DNA-dependent protein kinase catalytic subunit antibody | |
| DNA-PK catalytic subunit antibody | |
| DNA-PKcs antibody | |
| DNAPK antibody | |
| DNAPK catalytic subunit antibody | |
| DNPK 1 antibody | |
| DNPK1 antibody | |
| Hyper radiosensitivity of murine scid mutation, complementing 1 antibody | |
| Hyperradiosensitivity complementing 1, mouse, homolog of 1 antibody | |
| HYRC 1 antibody | |
| HYRC antibody | |
| HYRC1 antibody | |
| IMD26 antibody | |
| P350 antibody | |
| P460 antibody | |
| PKRDC antibody | |
| PRKDC antibody | |
| PRKDC_HUMAN antibody | |
| Protein Kinase DNA Activated Catalytic Polypeptide antibody | |
| XRCC 7 antibody | |
| XRCC7 antibody |
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Target information
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage.
Provider
Erpantech Laboratory
