Anti-DKK3 antibody
Specifications
| Product Cat#: | AB-06-1391 |
| Product type: | Primary antibody |
| Antigen: | DKK3 |
| Immunogen: | Purified recombinant fragment of human DKK3 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (C6-A5） |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Dickkopf 3 antibody |
| Dickkopf 3 homolog (Xenopus laevis) antibody | |
| Dickkopf 3 homolog antibody | |
| Dickkopf homolog 3 antibody | |
| Dickkopf related protein 3 antibody | |
| Dickkopf related protein 3 Precursor antibody | |
| Dickkopf WNT signaling pathway inhibitor 3 antibody | |
| Dickkopf, Xenopus, homolog of, 3 antibody | |
| Dickkopf-3 antibody | |
| Dickkopf-related protein 3 antibody | |
| Dickkopf3 antibody | |
| DKK 3 antibody | |
| Dkk-3 antibody | |
| DKK3 antibody | |
| DKK3_HUMAN antibody | |
| HDkk 3 antibody | |
| HDkk-3 antibody | |
| HDkk3 antibody | |
| Regulated in glioma antibody | |
| REIC antibody | |
| RIG antibody | |
| RIG-like 5-6 antibody | |
| RIG-like 7-1 antibody |
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Target information
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Provider
Erpantech Laboratory
