Anti-DKK1 antibody
Specifications
| Product Cat#: | AB-06-1390 |
| Product type: | Primary antibody |
| Antigen: | DKK1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:50-1:200); Immunocytochemistry (1:100-1:200); Immunofluorescence |
| Reactivity: | Human, Rat |
| Clonality (clone number): | Monoclonal (SC06-86) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Dickkopf 1 antibody |
| Dickkopf 1 homolog antibody | |
| Dickkopf 1 like antibody | |
| Dickkopf homolog 1 antibody | |
| Dickkopf like protein 1 antibody | |
| Dickkopf related protein 1 antibody | |
| Dickkopf WNT signaling pathway inhibitor 1 antibody | |
| Dickkopf-1 antibody | |
| Dickkopf-related protein 1 antibody | |
| DKK 1 antibody | |
| Dkk-1 antibody | |
| Dkk1 antibody | |
| DKK1_HUMAN antibody | |
| HDkk 1 antibody | |
| HDkk-1 antibody | |
| SK antibody |
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Target information
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Provider
Erpantech Laboratory