Anti-DIABLO antibody
Specifications
| Product Cat#: | AB-06-1380 |
| Product type: | Primary antibody |
| Antigen: | DIABLO |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:50-1:200); Immunocytochemistry (1:100-1:200); Immunofluorescence; Immunoprecipitation |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SC67-06) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 0610041G12Rik antibody |
| DBLOH_HUMAN antibody | |
| DBOH antibody | |
| DFNA64 antibody | |
| Diablo antibody | |
| Diablo homolog (Drosophila) antibody | |
| Diablo homolog antibody | |
| Diablo homolog mitochondrial antibody | |
| Diablo IAP binding mitochondrial protein antibody | |
| Diablo like protein antibody | |
| DIABLO S antibody | |
| Direct IAP binding protein with low pI antibody | |
| Direct IAP-binding protein with low pI antibody | |
| FLJ10537 antibody | |
| FLJ25049 antibody | |
| Mitochondrial antibody | |
| Mitochondrial Smac protein antibody | |
| Second mitochondria derived activator of caspase antibody | |
| Second mitochondria-derived activator of caspase antibody | |
| SMAC 3 antibody | |
| Smac antibody | |
| Smac protein antibody | |
| SMAC3 antibody |
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Target information
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Provider
Erpantech Laboratory
