Anti-Desmin antibody
Specifications
| Product Cat#: | AB-06-1363 |
| Product type: | Primary antibody |
| Antigen: | Desmin |
| Immunogen: | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to Desmin. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry (1:100); Immunocytochemistry (1:100) |
| Reactivity: | Human, mouse, zebrafish, Hybrid fish (crucian-carp) |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CMD1I antibody |
| CSM1 antibody | |
| CSM2 antibody | |
| DES antibody | |
| DESM_HUMAN antibody | |
| Desmin antibody | |
| FLJ12025 antibody | |
| FLJ39719 antibody | |
| FLJ41013 antibody | |
| FLJ41793 antibody | |
| Intermediate filament protein antibody | |
| OTTHUMP00000064865 antibody |
Target information
Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity . In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity).
Provider
Erpantech Laboratory
