Anti-DDX1 antibody
Specifications
| Product Cat#: | AB-06-1341 |
| Product type: | Primary antibody |
| Antigen: | DDX1 |
| Immunogen: | Purified recombinant fragment of human DDX1 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:450-1:2000); Immunohistochemistry (1:100-1:500); Flow Cytometry (1:100-1:200); Immunocytochemistry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (B2-E5) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ATP dependent helicase DDX1 antibody |
| ATP-dependent RNA helicase DDX1 antibody | |
| DBP RB antibody | |
| DBP-RB antibody | |
| DDX1 antibody | |
| DDX1_HUMAN antibody | |
| DEAD (Asp Glu Ala Asp) box polypeptide 1 antibody | |
| DEAD box 1 antibody | |
| DEAD box polypeptide 1 antibody | |
| DEAD box protein 1 antibody | |
| DEAD box protein retinoblastoma antibody | |
| DEAD/H (Asp Glu Ala Asp/His) box polypeptide 1 antibody |
Target information
Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5′ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3′-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation.
Provider
Erpantech Laboratory
