Anti-DCAMKL1 antibody
Specifications
| Product Cat#: | AB-06-1326 |
| Product type: | Primary antibody |
| Antigen: | DCAMKL1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1500); Immunohistochemistry (1:100-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JA11-03) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% HuaAn-ET1704-10-DCAMKL1Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Calcium/calmodulin-dependent protein kinase type I-like CPG16 antibody |
| CL1 antibody | |
| CLICK1 antibody | |
| Cpg16 antibody | |
| DCDC3A antibody | |
| Dcl antibody | |
| Dclk antibody | |
| Dclk1 antibody | |
| DCLK1_HUMAN antibody | |
| Doublecortin domain-containing protein 3A antibody | |
| Doublecortin-like and CAM kinase-like 1 antibody | |
| Doublecortin-like kinase 1 antibody | |
| KIAA0369 antibody | |
| Serine/threonine-protein kinase DCAMKL1 antibody | |
| Serine/threonine-protein kinase DCLK1 antibody |
Target information
Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to β-subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortinlike and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.
Provider
Erpantech Laboratory
