Anti-CytokeRatin 17 antibody
Specifications
| Product Cat#: | AB-06-1282 |
| Product type: | Primary antibody |
| Antigen: | CytokeRatin 17 |
| Immunogen: | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of mouse CK-17. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:2000); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:100-1:500); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 39.1 antibody |
| CK 17 antibody | |
| CK-17 antibody | |
| Cytokeratin-17 antibody | |
| K17 antibody | |
| K1C17_HUMAN antibody | |
| Keratin 17 antibody | |
| keratin 17 epitope S1 antibody | |
| keratin 17 epitope S2 antibody | |
| keratin 17 epitope S4 antibody | |
| Keratin 17, type I antibody | |
| Keratin antibody | |
| Keratin type I cytoskeletal 17 antibody | |
| keratin, type i cytoskeletal 17 [version 1] antibody | |
| Keratin-17 antibody | |
| KRT17 antibody | |
| PC antibody | |
| PC2 antibody | |
| PCHC1 antibody | |
| type I cytoskeletal 17 antibody |
Target information
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial “stem cells”. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Provider
Erpantech Laboratory
