Anti-Cytochrome C antibody
Specifications
| Product Cat#: | AB-06-1262 |
| Product type: | Primary antibody |
| Antigen: | Cytochrome C |
| Immunogen: | Amino acids 1-104 of cytochrome c of equine origin |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry (1:50-1:500); Flow Cytometry (1 μg per 1 x 106 cells); Immunofluorescence (1:50-1:500 ); Immunoprecipitation (1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) ) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (6G1) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5% BSA, 50% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CYC antibody |
| CYC_HUMAN antibody | |
| CYCS antibody | |
| Cytochrome c antibody | |
| Cytochrome c somatic antibody |
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Target information
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Provider
Erpantech Laboratory
