Anti-CYP2C19 antibody
Specifications
| Product Cat#: | AB-06-1249 |
| Product type: | Primary antibody |
| Antigen: | CYP2C19 |
| Immunogen: | KLH conjugated synthetic peptide derived from human CYP2C19 201-300/490 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10mM Tris-HCl buffer (pH7.4), 1% BSA, 50% glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AI266900 |
| CYP2C | |
| CYP2C19 | |
| CYP2C37 | |
| CYP2C50 | |
| Cyp2c54 | |
| CYP450-2C | |
| CPCJ | |
| CYPIIC17 | |
| CYPIIC19 | |
| EG404195 | |
| LOC293989 | |
| MGC109053 | |
| P450-11A | |
| P450C2C | |
| P450IIC19 | |
| CP2CJ_HUMAN Cytochrome P450 2C19 | |
| R)-limonene 6-monooxygenase | |
| (S)-limonene 6-monooxygenase | |
| (S)-limonene 7-monooxygenase | |
| CYPIIC17 | |
| CYPIIC19 | |
| Cytochrome P450-11A | |
| Cytochrome P450-254C |
Target information
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH–hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4′ position (PubMed:23959307).
Provider
Erpantech Laboratory
