Anti-CXCR4 antibody
Specifications
| Product Cat#: | AB-06-1212 |
| Product type: | Primary antibody |
| Antigen: | CXCR4 |
| Immunogen: | KLH conjugated synthetic peptide derived from mouse CXCR4 151-300/359 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (3μg/Test) |
| Reactivity: | Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10mM PBS buffer (pH7.4), 1% BSA, 15mM NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C-X-C chemokine receptor type 4 |
| CXC-R4 | |
| CXCR-4 | |
| Stromal cell-derived factor 1 receptor | |
| SDF-1 receptor | |
| Fusin | |
| Leukocyte-derived seven transmembrane domain receptor | |
| LESTR | |
| CD184 antigen |
Target information
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9295051, PubMed:9103415). Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237). Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (PubMed:9634238, PubMed:9689100).
Provider
Erpantech Laboratory
