Anti-Cullin 2 antibody
Specifications
| Product Cat#: | AB-06-1200 |
| Product type: | Primary antibody |
| Antigen: | Cullin 2 |
| Immunogen: | Recombinant protein within human Cullin 2 aa 1-200 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry (1:50-1:200); Immunoprecipitation (1:10-1:50) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JG72-31) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Cul2 antibody |
| CUL 2 antibody | |
| CUL-2 antibody | |
| CUL2 antibody | |
| CUL2_HUMAN antibody | |
| cullin 2 antibody | |
| cullin homolog 2 antibody | |
| Cullin-2 antibody |
Target information
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Provider
Erpantech Laboratory
