Anti-Cubilin antibody
Specifications
| Product Cat#: | AB-06-1198 |
| Product type: | Primary antibody |
| Antigen: | Cubilin |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500); Immunohistochemistry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JB42-13) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 60 kDa receptor antibody |
| cubilin (intrinsic factor-cobalamin receptor) antibody | |
| Cubilin antibody | |
| Cubilin precursor antibody | |
| Cubn antibody | |
| CUBN_HUMAN antibody | |
| IFCR antibody | |
| Intestinal intrinsic factor receptor antibody | |
| intrinsic factor B12-receptor antibody | |
| Intrinsic factor-cobalamin receptor antibody | |
| Intrinsic factor-vitamin B12 receptor antibody | |
| megaloblastic anemia 1 antibody | |
| MGA1 antibody |
Target information
Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:9572993, PubMed:10371504, PubMed:11717447, PubMed:11606717, PubMed:14576052). Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PubMed:9572993, PubMed:14576052). Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium (PubMed:9572993). Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
Provider
Erpantech Laboratory