Anti-CRTC1 antibody
Specifications
| Product Cat#: | AB-06-1172 |
| Product type: | Primary antibody |
| Antigen: | CRTC1 |
| Immunogen: | Purified recombinant fragment of human CRTC1 expressed in E. Coli |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:1000); Flow Cytometry (1:100-1:200); Immunocytochemistry (1:100-1:500) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (A2-B5) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | KIAA0616 antibody |
| CREB regulated transcription coactivator 1 antibody | |
| CREB-regulated transcription coactivator 1 antibody | |
| CRTC1 antibody | |
| CRTC1_HUMAN antibody | |
| FLJ14027 antibody | |
| MECT 1 antibody | |
| Mucoepidermoid carcinoma translocated 1 antibody | |
| Mucoepidermoid carcinoma translocated protein 1 antibody | |
| TORC-1 antibody | |
| TORC1 antibody | |
| Transducer of CREB protein 1 antibody | |
| Transducer of regulated cAMP response element binding protein 1 antibody | |
| Transducer of regulated cAMP response element-binding protein (CREB) 1 antibody | |
| Transducer of regul |
Target information
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ‘Ser-133’ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Provider
Erpantech Laboratory
