Anti-Cleaved PARP antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Cleaved PARP |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000); Immunocytochemistry (1:50-1:200); Immunoprecipitation; Flow Cytometry (1:50-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (SU0314) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ADP-ribosyltransferase diphtheria toxin-like 1 antibody |
| ADPRT 1 antibody | |
| ADPRT antibody | |
| ADPRT1 antibody | |
| APOPAIN antibody | |
| ARTD1 antibody | |
| NAD(+) ADP-ribosyltransferase 1 antibody | |
| PARP antibody | |
| PARP-1 antibody | |
| PARP1 antibody | |
| PARP1_HUMAN antibody | |
| Poly [ADP-ribose] polymerase 1 antibody | |
| Poly ADP ribose polymerase 1 antibody | |
| Poly[ADP-ribose] synthase 1 antibody | |
| PPOL antibody | |
| SCA1 antibody |
Target information
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:25043379, PubMed:26344098). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD+ is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2′-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:7852410, PubMed:9315851, PubMed:19764761, PubMed:25043379). Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF and CHFR (PubMed:17396150, PubMed:19764761). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). Probably also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:30257210). Catalyzes the poly-ADP-ribosylation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the base excision repair (BER) pathway by catalyzing the poly-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272).
Provider
Erpantech Laboratory