No products in the cart.

Anti-Cdk9 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-1011
Anti-Cdk9 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-1011
Product type: Primary antibody
Antigen: Cdk9
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:900); Immunohistochemistry (1:40-1:200); Immunocytochemistry (1:40-1:200); Immunoprecipitation; Immunofluorescence
Reactivity: Human
Clonality (clone number): Monoclonal (SD204-07)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: HMG box transcription factor 4 antibody
HTCF 4 antibody
HTCF-4 antibody
T cell factor 4 antibody
T cell specific HMG box antibody
T cell specific transcription factor 4 antibody
T-cell factor 4 antibody
T-cell-specific transcription factor 4 antibody
TCF 4 antibody
TCF-4 antibody
TCF4 antibody
TCF7L2 antibody
TCF7L2 protein antibody
TF7L2_HUMAN antibody
Transcription factor 7 like 2 antibody
Transcription factor 7 like 2 T cell specific HMG box antibody
Transcription factor 7-like 2 antibody
Show More

Target information

Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on ‘Ser-2’ in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.

Provider

Erpantech Laboratory

download

MSDS-AB-06-1011.pdf (194 downloads )