Anti-Cdk8 antibody
Specifications
| Product Cat#: | AB-06-1010 |
| Product type: | Primary antibody |
| Antigen: | Cdk8 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:900-1:2000); Immunoprecipitation |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SN2030) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Cdk8 antibody |
| CDK8 protein kinase antibody | |
| CDK8_HUMAN antibody | |
| Cell Division Kinase 8 antibody | |
| Cell division protein kinase 8 antibody | |
| Cyclin Dependent kinase 8 antibody | |
| Cyclin-dependent kinase 8 antibody | |
| K35 antibody | |
| Mediator complex subunit cdk8 antibody | |
| Mediator of RNA polymerase II transcription subunit cdk8 antibody | |
| Protein kinase K35 antibody |
Target information
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Provider
Erpantech Laboratory
