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Anti-Cdk6 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-1007
Anti-Cdk6 antibody
Erpan Tech In stock

Specifications        

Product Cat#: AB-06-1007
Product type: Primary antibody
Antigen: Cdk6
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:900-1:2000); Immunohistochemistry (1:40-1:200); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:40-1:200); Immunofluorescence
Reactivity: Human, Mouse, Rat
Clonality (clone number): Monoclonal (SD20-50)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: CDK 6 antibody
CDK6 antibody
CDK6_HUMAN antibody
Cell division protein kinase 6 antibody
Crk 2 antibody
Crk2 antibody
Cyclin dependent kinase 6 antibody
Cyclin-dependent kinase 6 antibody
MGC59692 antibody
P40 antibody
PLSTIRE antibody
Serine/threonine protein kinase PLSTIRE antibody
Serine/threonine-protein kinase PLSTIRE antibody
STQTL11 antibody
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Target information

Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases.

Provider

Erpantech Laboratory

download

MSDS-AB-06-1007.pdf (148 downloads )