Anti-Cdk4 antibody
Specifications
| Product Cat#: | AB-06-1003 |
| Product type: | Primary antibody |
| Antigen: | Cdk4 |
| Immunogen: | This antibody is produced by immunizing mice with recombinant protein corresponding to a region of Cdk4 (aa 80-320). |
| Species immunized: | Mouse |
| Isotype: | IgG2c |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry (1:40-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (5-C3-G3) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Cdk 4 antibody |
| Cdk4 antibody | |
| CDK4 protein antibody | |
| CDK4_HUMAN antibody | |
| Cell division kinase 4 antibody | |
| Cell division protein kinase 4 antibody | |
| CMM 3 antibody | |
| CMM3 antibody | |
| Crk3 antibody | |
| Cyclin dependent kinase 4 antibody | |
| Cyclin-dependent kinase 4 antibody | |
| Melanoma cutaneous malignant 3 antibody | |
| MGC14458 antibody | |
| P34 cdk4 antibody | |
| PSK J3 antibody | |
| PSK-J3 antibody |
Target information
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Provider
Erpantech Laboratory
