Anti-CD3D antibody
Specifications
| Product Cat#: | AB-06-0916 |
| Product type: | Primary antibody |
| Antigen: | CD3D |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:800-1:2000 ); Immunohistochemistry ( 1:80-1:200 ); Immunocytochemistry ( 1:80-1:500 ); Flow Cytometry ( 1:50-1:100 ); Immunoprecipitation |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal ( JJ08-97 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CD3 Antigen Delta Subunit Antibody |
| CD3 Delta Antibody | |
| CD3d Antibody | |
| CD3d Antigen Delta Polypeptide (TiT3 Complex) Antibody | |
| CD3d Molecule Delta (CD3-TCR Complex) Antibody | |
| CD3D_HUMAN Antibody | |
| IMD19 Antibody | |
| OKT3 Delta Chain Antibody | |
| T cell Receptor T3 delta Chain Antibody | |
| T-cell Receptor T3 delta ChainAntibody | |
| T-cell Surface Glycoprotein CD3 Delta Chain Antibody | |
| T3D Antibody |
Target information
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells.
Provider
Erpantech Laboratory