Anti-CD183 antibody
Specifications
| Product Cat#: | AB-06-4834 |
| Product type: | Primary antibody |
| Antigen: | CD183 |
| Immunogen: | Purified recombinant fragment of human CD183 (AA: extra mix) expressed in E. Coli. |
| Species immunized: | Rabbit |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000); Flow Cytometry (1:50-1:200); Immunohistochemistry-Paraffin (1:50-200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, [5C10E6] |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein G affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Non-conjugated |
| Alternative names: | C-X-C chemokine receptor type 3 antibody |
| CD 183 antibody | |
| CD182 antibody | |
| CD183 antibody | |
| Chemokine (C X C motif) receptor 3 antibody | |
| Chemokine (C X C) receptor 3 antibody | |
| Chemokine CXC Motif Receptor 3 antibody | |
| CKR L2 antibody | |
| CKR-L2 antibody | |
| CKRL2 antibody | |
| CMKAR3 antibody | |
| CXC-R3 antibody | |
| CXCR-3 antibody | |
| CXCR3 antibody | |
| CXCR3_HUMAN antibody | |
| G Protein Coupled Receptor 9 antibody | |
| G protein-coupled receptor 9 antibody | |
| GPR9 antibody | |
| Interferon-inducible protein 10 receptor antibody | |
| IP-10 receptor antibody | |
| IP10 antibody | |
| IP10 R antibody | |
| IP10 receptor antibody | |
| IP10-R antibody | |
| IP10R antibody | |
| Mig R antibody | |
| Mig receptor antibody | |
| Mig-R antibody | |
| MIGR antibody |
Target information
Isoform 1:
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716).
Binds to CCL21. Probably promotes cell chemotaxis response.
Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716).
Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
Isoform 3:
Mediates the activity of CXCL11.
Provider
Erpantech Laboratory
