Anti-CD163 antibody
Specifications
| Product Cat#: | AB-06-0864 |
| Product type: | Primary antibody |
| Antigen: | CD163 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:800-1:2000 ); Immunoprecipitation; Immunohistochemistry ( 1:80-1:200 ); Flow Cytometry ( 1:30-1:100 ) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal ( JA51-30 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C163A_HUMAN Antibody |
| CD 163 Antibody | |
| CD163 Antibody | |
| CD163 Antigen Antibody | |
| CD163 Molecule Antibody | |
| Hemoglobin Scavenger Receptor Antibody | |
| M130 Antibody | |
| M130 Antigen Precursor Antibody | |
| Macrophage Associated Antigen Antibody | |
| MM130 Antibody | |
| OTTHUMP00000238617 Antibody | |
| OTTHUMP00000238618 Antibody | |
| OTTHUMP00000238619 Antibody | |
| OTTHUMP00000238620 Antibody | |
| SCARI1 Antibody | |
| Scavenger Receptor Cysteine Rich Type 1 Protein M130 Antibody | |
| sCD163 Antibody | |
| Soluble CD163 Antibody |
Target information
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Provider
Erpantech Laboratory