No products in the cart.

Anti-CD11c antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-0839
Anti-CD11c antibody
Erpan Tech Out of stock

Specifications        

Product Cat#: AB-06-0839
Product type: Primary antibody
Antigen: CD11c
Immunogen: Peptide
Species immunized: Mouse
Isotype: IgG1
Applications: Immunoprecipitation ( 1-4 μg per 100-500 μg of total protein(1 ml of cell lysate) ); Immunofluorescence ( 1:80-1:500 ); Flow Cytometry ( 1-3 μg per 1 x 106 cells )
Reactivity: Mouse and Human
Clonality (clone number): Monoclonal ( 4G2 )
Form: Liquid
Buffer: Tris-HCl buffer ( pH7. 4), 1 % BSA, 40 % glycerol, 0.05 % NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Antigen CD11b ( p170 ) Antibody
Antigen CD11b p170 Antibody
CD11 Antigen Like Family Member B Antibody
CD11 Antigen-like Family Member B Antibody
CD11b Antibody
Show More

Target information

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).

Provider

Erpantech Laboratory

download

MSDS-AB-06-0839.pdf (240 downloads )