Anti-CBX4 antibody
Specifications
| Product Cat#: | AB-06-0794 |
| Product type: | Primary antibody |
| Antigen: | CBX4 |
| Immunogen: | KLH conjugated synthetic peptide derived from human CBX4 401-500/560 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:550-1:2000) |
| Reactivity: | Mouse, Rat, Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300, 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CBX 4 |
| CBX4 | |
| Cbx4 chromobox homolog 4 (Drosophila Pc class) | |
| CBX4_HUMAN | |
| Chromobox homolog 4 (Pc class homolog, Drosophila) | |
| Chromobox homolog 4 | |
| Chromobox protein homolog 4 | |
| E3 SUMO protein ligase CBX 4 | |
| E3 SUMO protein ligase CBX4 | |
| E3 SUMO-protein ligase CBX4 | |
| hPc 2 | |
| NBP 16 | |
| NS5ATP1 binding protein 16 | |
| Pc 2 | |
| Pc class 2 homolog | |
| Pc class homolog | |
| Pc class homolog Drosophila | |
| PC2 |
Target information
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at ‘Lys-9’ (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity).
Provider
Erpantech Laboratory
