Anti-Caveolin-1 Mouse Monoclonal antibody
Specifications
| Product Cat#: | AB-06-4964 |
| Product type: | Primary antibody |
| Antigen: | Caveolin-1 |
| Immunogen: | Recombinant protein within human Caveolin-1 aa 1-150. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:500-2000) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, A7E4 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH 7.4), 0.1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/mL |
| Purity: | Protein G affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | BSCL3 antibody |
| CAV antibody | |
| CAV1 antibody | |
| CAV1_HUMAN antibody | |
| caveolae protein, 22 kD antibody | |
| caveolin 1 alpha isoform antibody | |
| caveolin 1 beta isoform antibody | |
| Caveolin 1 caveolae protein 22kDa antibody | |
| Caveolin-1 antibody | |
| Caveolin1 antibody | |
| cell growth-inhibiting protein 32 antibody | |
| CGL3 antibody | |
| LCCNS antibody | |
| MSTP085 antibody | |
| OTTHUMP00000025031 antibody | |
| PPH3 antibody | |
| VIP 21 antibody | |
| VIP21 antibody |
Target information
May act as a scaffolding protein within caveolar membranes (PubMed:11751885).
Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).
Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217).
Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity).
Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).
Provider
Erpantech Laboratory
