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Anti-Caspase-14 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-0751
Anti-Caspase-14 antibody
Erpan Tech In stock

Specifications        

Product type: Primary antibody
Antigen: Caspase-14
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:1000); Immunocytochemistry/Immunofluorescence (1:100-1:200); Immunohistochemistry (1:100-1:200); Immunoprecipitation; Flow Cytometry (1:40-1:100)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Monoclonal, JJ089-01
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3.
Concentration: 1mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Apoptosis related cysteine protease antibody
CASP 14 antibody
CASP-14 antibody
CASP14 antibody
Caspase 14 apoptosis related cysteine protease antibody
Caspase 14 precursor antibody
Caspase-14 subunit p10 antibody
Caspase14 antibody
CASPE_HUMAN antibody
MGC119078 antibody
MGC119079 antibody
MICE antibody
Mini ICE antibody
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Target information

Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).

Provider

Erpantech Laboratory

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