Anti-Caspase-14 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Caspase-14 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000); Immunocytochemistry/Immunofluorescence (1:100-1:200); Immunohistochemistry (1:100-1:200); Immunoprecipitation; Flow Cytometry (1:40-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, JJ089-01 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Apoptosis related cysteine protease antibody |
| CASP 14 antibody | |
| CASP-14 antibody | |
| CASP14 antibody | |
| Caspase 14 apoptosis related cysteine protease antibody | |
| Caspase 14 precursor antibody | |
| Caspase-14 subunit p10 antibody | |
| Caspase14 antibody | |
| CASPE_HUMAN antibody | |
| MGC119078 antibody | |
| MGC119079 antibody | |
| MICE antibody | |
| Mini ICE antibody |
Target information
Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
Provider
Erpantech Laboratory