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Anti-Caspase-1 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-0747
Anti-Caspase-1 antibody
Erpan Tech In stock

Specifications        

Product type: Primary antibody
Antigen: Caspase 1
Immunogen: Peptide
Species immunized: Rabbit
Isotype: IgG
Applications: Immunocytochemistry (1:100-1:200); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:40-1:100)
Reactivity: Human
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 0.05% NaN3 and 40% Glycerol.
Concentration: 1mg/ml
Purity: Peptide affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: CASP-1 antibody
CASP1 antibody
CASP1_HUMAN antibody
Caspase 1 antibody
Caspase-1 subunit p10 antibody
ICE antibody
IL-1 beta-converting enzyme antibody
IL-1BC antibody
IL1 beta converting enzyme antibody
IL1B convertase antibody
Interleukin 1 beta convertase antibody
Interleukin 1B converting enzyme antibody
Interleukin-1 beta convertase antibody
Interleukin-1 beta-converting enzyme antibody
p45 antibody
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Target information

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547).

Provider

Erpantech Laboratory

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