Anti-Caspase-1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Caspase 1 |
| Immunogen: | This antibody is produced by immunizing mice with recombinant protein corresponding to a region of Caspase-1. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:1000-1:4000); Immunohistochemistry (1:100-1:500); Immunocytochemistry (1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, B0-6 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 0.5% BSA, 0.05% NaN3 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CASP-1 antibody |
| CASP1 antibody | |
| CASP1_HUMAN antibody | |
| Caspase 1 antibody | |
| Caspase-1 subunit p10 antibody | |
| ICE antibody | |
| IL-1 beta-converting enzyme antibody | |
| IL-1BC antibody | |
| IL1 beta converting enzyme antibody | |
| IL1B convertase antibody | |
| Interleukin 1 beta convertase antibody | |
| Interleukin 1B converting enzyme antibody | |
| Interleukin-1 beta convertase antibody | |
| Interleukin-1 beta-converting enzyme antibody | |
| p45 antibody |
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Target information
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly (PubMed:20197547).
Provider
Erpantech Laboratory
