Anti-Calcineurin A antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Calcineurin A |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1000); Flow Cytometry (1:40-1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, JA64-11 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.05% NaN3 and 40% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Alpha isoform formerly PPP2B antibody |
| Calcineurin A alpha antibody | |
| Calcineurin A1 antibody | |
| CalcineurinA antibody | |
| Calmodulin dependent calcineurin A subunit alpha isoform antibody | |
| Calmodulin-dependent calcineurin A subunit alpha isoform antibody | |
| CALN antibody | |
| CALNA 1 antibody | |
| CALNA antibody | |
| CALNA1 antibody | |
| CAM PRP catalytic subunit antibody | |
| CAM-PRP catalytic subunit antibody | |
| CCN 1 antibody | |
| CCN1 antibody | |
| CNA 1 antibody | |
| CNA alpha antibody | |
| CNA antibody | |
| CNA1 antibody | |
| PP2BA_HUMAN antibody | |
| PPP2B antibody | |
| Ppp3ca antibody | |
| Protein phosphatase 2B catalytic subunit antibody | |
| Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody | |
| Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA antibody | |
| Protein phosphatase 3 catalytic subunit alpha isozyme antibody | |
| Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody |
Target information
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722). In response to increased Ca2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). May dephosphorylate CRTC2 at ‘Ser-171’ resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118).
Provider
Erpantech Laboratory
