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Anti-C9orf72 antibody

SKU Product Brand Unit Availability Price Quantity  
AB-06-0677
Anti-C9orf72 antibody
Erpan Tech In stock

Specifications        

Product type: Primary antibody
Antigen: C9orf72
Isotype: IgG
Species immunized: Rabbit
Immunogen: KLH conjugated synthetic peptide derived from human C9orf72 391-481/481
Applications: Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-800); Flow Cytometry (1ug/test)
Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 1*TBS (pH7.4), 1%BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration: 1mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: chromosome 9 open reading frame 72
CI072_HUMAN
MGC23980
Uncharacterized protein C9orf72
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Target information

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity).

Provider

Erpantech Laboratory

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