Anti-BRN3A antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | BRN3A |
| Immunogen: | KLH conjugated synthetic peptide derived from human BRN3A 325-419/419 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:500-800); Flow Cytometry (1ug/test) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Brain specific homeobox/POU domain protein 3A |
| Brn 3.0 | |
| BRN 3A | |
| Brn3 | |
| Homeobox/POU domain protein RDC 1 | |
| Homeobox/POU domain protein RDC1 | |
| Oct T1 | |
| OctT1 | |
| POU Domain Class 4 Transcription Factor 1 | |
| POU4F1 | |
| RDC 1 |
Target information
Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5′-ATGCAAAT-3′ in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.
Provider
Erpantech Laboratory
