Anti-BRCA1 Mouse Monoclonal antibody
Specifications
| Product Cat#: | AB-06-4968 |
| Product type: | Primary antibody |
| Antigen: | BRCA1 |
| Immunogen: | Recombinant protein within Human BRCA1 aa 1-200 / 1,863. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Immunohistochemistry-Paraffin (1:1000-2000) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal, A7E3 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH 7.4), 0.1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 2 mg/mL |
| Purity: | Protein G affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | BRCA 1 antibody |
| BRCA1 antibody | |
| BRCA1 DNA repair associated antibody | |
| BRCA1/BRCA2 containing complex subunit 1 antibody | |
| BRCA1/BRCA2-containing complex, subunit 1 antibody | |
| BRCA1_HUMAN antibody | |
| BRCAI antibody | |
| BRCC 1 antibody | |
| BRCC1 antibody | |
| Breast and ovarian cancer susceptibility protein 1 antibody | |
| Breast Cancer 1 antibody | |
| Breast Cancer 1 Early Onset antibody | |
| Breast cancer type 1 susceptibility protein antibody | |
| BROVCA1 antibody | |
| FANCS antibody | |
| IRIS antibody | |
| PNCA4 antibody | |
| PPP1R53 antibody | |
| Protein phosphatase 1 regulatory subunit 53 antibody | |
| PSCP antibody | |
| RING finger protein 53 antibody | |
| RNF53 antibody |
Target information
function
E3 ubiquitin-protein ligase that specifically mediates the formation of ‘Lys-6’-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748).
It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688).
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172).
Regulates centrosomal microtubule nucleation (PubMed:18056443).
Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748).
Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909).
Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698).
Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211).
Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604).
Acts as a transcriptional activator (PubMed:20160719).
Provider
Erpantech Laboratory
