Anti-BNIP3 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | BNIP3 |
| Immunogen: | Purified recombinant fragment of human BNIP3 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:1000-1:2000); Immunohistochemistry (1:100-1:500); Immunocytochemistry (1:100-1:200); Flow Cytometry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, F7-A5 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | BCL2 Adenovirus E1B 19kDa Interacting Protein 3 antibody |
| BCL2/adenovirus E1B 19 kDa protein interacting protein 3 antibody | |
| BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 antibody | |
| BNIP 3 antibody | |
| BNIP3 antibody | |
| BNIP3_HUMAN antibody | |
| NIP 3 antibody | |
| NIP3 antibody |
Target information
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Provider
Erpantech Laboratory
