Anti-Bmi1 antibody
Specifications
| Product type: | Primary antibody |
| Antigen: | Bmi1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunocytochemistry/Immunofluorescence (1:100-1:200); Immunohistochemistry (1:100-1:200) |
| Reactivity: | Rat, Human |
| Clonality (clone number): | Monoclonal, JJ093-3 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | B lymphoma Mo MLV insertion region (mouse) antibody |
| B lymphoma Mo MLV insertion region 1 homolog antibody | |
| Bmi 1 antibody | |
| BMI1 antibody | |
| BMI1 polycomb ring finger oncogene antibody | |
| BMI1_HUMAN antibody | |
| Flvi 2/bmi 1 antibody | |
| FLVI2/BMI1 antibody | |
| MGC12685 antibody | |
| Murine leukemia viral (bmi 1) oncogene homolog antibody | |
| Oncogene BMI 1 antibody | |
| PCGF 4 antibody | |
| PCGF4 antibody | |
| Polycomb complex protein BMI 1 antibody | |
| Polycomb complex protein BMI-1 antibody | |
| Polycomb group protein Bmi1 antibody | |
| Polycomb group ring finger 4 antibody | |
| Polycomb group RING finger protein 4 antibody | |
| RING finger protein 51 antibody | |
| RNF 51 antibody | |
| RNF51 antibody |
Target information
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
Provider
Erpantech Laboratory